HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(6-Chloropyrazin-2-yl)piperazin-1-yl]butan-1-amine → Hexahydro-3-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-1,5-methanocyclopent[d]azepine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(6-Chloropyrazin-2-yl)piperazin-1-yl]butan-1-amine | HCID 14086526 | — |
| Reactant | Bicyclo[3.3.0]-octane-2,4-dicarboxylic anhydride | HCID 53869218 | — |
| Product | Hexahydro-3-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-1,5-methanocyclopent[d]azepine-2,4(1H,3H)-dione | HCID 14370160 | — |
Reaction Steps
The title compound was prepared from 4.58 g (25.4 mmoles) of bicyclo[3.3.0]-octane-2,4-dicarboxylic anhydride and 7.10 g (26 mmoles) of 1-(4-aminobutyl)-4-(6-chloro-2-pyrazinyl)-piperazine following the procedure in Example 1. 7.24 g of the hydrochloride salt was isolated as the one-quarter hydrate, m.p. 223°-225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04824999 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-06151931f9d048ed8d5a896b5d2dc735 |
| Source note | uspto-grants-1989_04 |