HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetoacetate → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-hydroxy-5-methylthiophene-2-carboxylate | HCID 587860 | 52.3% |
Reaction Steps
Prepared by the method described in Example 1 from ethyl acetoacetate (130 g, 1.0 mole), methyl thioglycolate (212 g, 2.0 moles) and sodium (53 g, 2.3 moles). The crude product is shaken with two portions of dichloromethane, filtered, and the filtrate stripped of solvent under reduced pressure to afford the product (90.1 g); mp 50°-53° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04824958 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-a0d5afd534c549998c46e0ca23cb59e2 |
| Source note | uspto-grants-1989_04 |