HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-chloroacrylate → Methyl 3-hydroxy-1H-pyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-chloroacrylate | HCID 6659 | — |
| Reactant | Glycine methyl ester | HCID 69221 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Product | Methyl 3-hydroxy-1H-pyrrole-2-carboxylate | HCID 54711834 | — |
Reaction Steps
Prepared by the method described in Example 101 from methyl glycinate (22 g, 0.25 moles), methyl α-chloroacrylate (29.8 g, 0.25 moles), and sodium (17 g, 0.74 moles). Following filtration through silica gel and evaporation of the filtrate, the product is obtained pure and crystalline (18.6 g ; mp 100°-102° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04824958 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-9ef35350f43142fab7e8c6570f4c8ce5 |
| Source note | uspto-grants-1989_04 |