Water → HCID 14873720, compound

Participants

Reaction Steps

Methyl 4,5-dibromo-3-(1-methylethoxy)-1H-pyrrole-2-carboxylate (1.5 g, 0.004 moles) is stirred under nitrogen in DMSO (100 mL) at room temperature. Potassium tert-butoxide (2.5 g, 0.022 moles) is added. After 12 hours the mixture is stirred into water (600 mL) and extracted with ether twice. The ether extracts are discarded, and the aqueous phase is acidified with H3PO4, then extracted with CH2Cl2 (3x). The combined extracts are washed with brine and dried over MgSO4. Removal of the solvent under reduced pressure left the product as a clear oil (1.4 g), sufficiently pure for further use.

Provenance & Evidence