反应详情

A mixture of 2-(4-bromophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid ethyl ester (7.00 g, 0.0194 mole) sodium hydroxide pellets (0.88 g, 0.0220 mole), and 95% ethanol (100 ml) was refluxed for 1 hr. The reaction mixture was cooled and filtered. The filter cake (7.3 g) was dissolved in warm water, acidified with concentrated hydrochloric acid, and chilled. The precipitated solid was collected by filtration and the filter cake was rinsed with water, giving 5.6 g (87%) of crystals. Recrystallization from tetrahydrofuran-methanol gave 5.4 g of white needles, mp 264°-267° C.

1. temperaturewas refluxed for 1 hr
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. dissolutionThe filter cake (7.3 g) was dissolved in warm water
5. temperaturechilled
6. filtrationThe precipitated solid was collected by filtration
7. washthe filter cake was rinsed with water