反应详情

N-[3-[(4-bromobenzoyl)amino]-2-pyridinyl]glycine ethyl ester (4.6 g, 0.012 mole) was heated in glass in a 190° C. oil bath for 1/2 hour. The melt was cooled and methylene chloride (150 ml) added. The solution was twice treated with 25 g of Florisil® and filtered. The filtrate was concentrated vacuo and the residue recrystallized from isopropyl ether-ethanol to give 2.1 g (49%) of a white flocculent solid, mp 138°-139° C.

1. temperatureThe melt was cooled
2. filtrationfiltered
3. concentrationThe filtrate was concentrated vacuo
4. customthe residue recrystallized from isopropyl ether-ethanol
5. customto give 2.1 g (49%) of a white flocculent solid, mp 138°-139° C.