Hydrochloric Acid → HCID 70383008, compound

Participants

Reaction Steps

To the compound of Example 5 (1.09 g) in methanol (40 ml) was added 10.9M hydrogen chloride in methanol (0.41 ml) and 10% palladium on charcoal (0.1 g). The mixture was hydrogenated at 50° until hydrogen uptake ceased. The catalyst was removed by filtration and the filtrate evaporated to give a white solid. Recrystallisation from propan-1-ol gave the title compound (0.56 g) m.p. darkens from 225° and melts 265°-270° (d), NMR (DMSO-d6) τ 2.7-3.2 (4H, multiplets, aromatic), 5.85 (1H, m, 3a-H), 6.2-6.5 and 6.8-7.3 (6H, multiplets, 1-H2, 3-H2 and 9-H2), and 7.77 (1H, m, 9a-H).

Provenance & Evidence