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HRID622080

反应详情

EQUATION

反应方程式

HRID 622080 的结构方程式

REACTANTS

反应物

3
结构：CC(C)N=C=NC(C)C
HCID12734

Diisopropylcarbodiimide

C7H14N2

结构：O=C(O)c1ccc(Cl)cc1[N+](=O)[O-]
HCID80475

4-Chloro-2-nitrobenzoic acid

C7H4ClNO4

结构：CCCn1c(N)c(N=O)c(=O)n(CCC)c1=O
HCID5182018

6-Amino-5-nitroso-1,3-dipropylpyrimidine-2,4(1H,3H)-dione

C10H16N4O3

PRODUCTS

生成物

1
结构：CCCn1c(=O)c2[nH]c(-c3ccc(Cl)cc3N)nc2n(CCC)c1=O
HCID92411

1,3-Dipropyl-8-(2-amino-4-chlorophenyl)xanthine

C17H20ClN5O2

收率 2.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine was synthesized by a modification of the method of Pfleiderer and Kempter (Ang. Int. Ed. 6:259-260, 1967). 2-nitro-4-chlorobenzoic acid (0.02 mol) was dissolved in 30 ml of methanol. 1,3-dipropyl-5-nitroso-6-aminouracil (0.01 mol) was added with stirring, followed by 0.2 mol diisopropylcarbodiimide (DICD).