Potassium Hydroxide → HCID 13525043, compound

Participants

Reaction Steps

1,3-dipropyl-8-(2-amino-4-nitrophenyl)xanthine (0.007 mol) was dissolved in 20 ml boiling 2.5N KOH. Five ml of 22% ammonium sulfide was added, and the solution was removed from heat after 1 minute. HCl was added to pH 8 in a hood, and the product was collected by filtration and washed with water. About 25% of the product was a sulfur-containing impurity. Since this impurity appeared to protect the xanthine from oxidation, no attempt was made to further purify the xanthine. 8-(2,4-diaminophenyl)theophylline was synthesized in the same way.

Provenance & Evidence