Ammonia → HCID 3568004, compound

HRID 622115Notes

Reaction equation

HRID 622115 reaction equation
C(C[C:7]1[N:11](C)[C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[N:9][C:8]=1C)(OCC)=O.N>CO>[CH3:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][S:13][C:10]2[NH:11][CH:7]=[CH:8][N:9]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14257106HCID 14257106, compound

Product 1

HCID 3568004HCID 3568004, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

A solution of 5-carbethoxymethyl-1,4-dimethyl-2-(4-methoxybenzylthio)imidazole (2 g, 6 mmoles) in methanol (15 ml) was cooled in an acetone/dry ice bath and treated with liquid ammonia (15 ml). The mixture was warmed to 25° C. and concentrated in vacuo to afford 5-(aminocarbonylmethyl)-1,4-dimethyl(-2-(4-methoxybenzylthio)imidazole.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-37d749966c2548009557d03fdff3b806
Source dataset
uspto-grants-1988_09
Patent number
US04769386

Reaction notes

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