反应详情

1-Bromo-12-methyl-11-tridecene (4.4 g, 16 mmoles) and triphenylphosphine (4.65 g, 17 mmoles) dissolved in acetonitrile (80 ml) were heated to reflux for 4 days, cooled and concentrated in vacuo. The residue was chromatographed on silica gel eluted with chloroform and then with methanol-chloroform (2:3). Fractions containing the product were concentrated in vacuo, triturated with ether, filtered and dried in vacuo to afford the desired phosphonium salt.

1. temperaturewere heated
2. temperatureto reflux for 4 days
3. temperaturecooled
4. concentrationconcentrated in vacuo
5. customThe residue was chromatographed on silica gel
6. washeluted with chloroform
7. additionFractions containing the product
8. concentrationwere concentrated in vacuo
9. customtriturated with ether
10. filtrationfiltered
11. customdried in vacuo