Isopropylamine → HCID 70416795, compound

Participants

Reaction Steps

A mixture of 3 g of 3-(4-epoxymethoxyphenyl)thieno[2,3-d]isoxazole (prepared from epibromohydrin and 3-(4-hydroxyphenyl)thieno[2,3-d]isoxazole in substantially the same manner as Example 5), 5 ml of absolute ethanol and 5 ml of isopropylamine was refluxed for three hours. The excess amine and ethanol were removed under a reduced pressure, leaving a residue. The crude product was extracted into 400 ml of ethyl acetate/ether (1:1) and shaken with ice-cold (10%) hydrochloric acid. The aqueous solution was separated and basified with concentrated NH3 to liberate the product. Extraction with ethyl acetate/ether (1:1) followed by washing and drying yielded a colorless solid weighing 2.8 g. The free base was converted to crystalline maleate in ethyl acetate/ether and recrystallized from methanol/ether to afford plates, m.p. 153°-155° C.

Provenance & Evidence