5-Bromopentanenitrile → HCID 178439679, compound

HRID 622241Notes

Reaction equation

HRID 622241 reaction equation
[OH:1][C:2]1[C:15]([CH2:16][CH2:17][CH3:18])=[C:14]([OH:19])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Br[CH2:21][CH2:22][CH2:23][CH2:24][C:25]#[N:26].[NH:27]1C=N[N:29]=[N:28]1>>[C:4]([C:3]1[CH:12]=[CH:13][C:14]([O:19][CH2:21][CH2:22][CH2:23][CH2:24][C:25]2[NH:26][N:29]=[N:28][N:27]=2)=[C:15]([CH2:16][CH2:17][CH3:18])[C:2]=1[OH:1])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 794355-BromopentanenitrileHCID 13019373(2,4-Dihydroxy-3-propylphenyl)(phenyl)methanoneHCID 178418441HCID 178418441, compound

Product 1

HCID 178439679HCID 178439679, compound

Procedure

The title compound was prepared by first reacting 7.68 g. of 2,4-dihydroxy-3-propylbenzophenone with 4.86 g. of 5-bromovaleronitrile according to the procedure in Example 21. The reaction afforded 8.2 g. of the nitrile intermediate of the title compound. This nitrile intermediate was then converted to the tetrazole following the procedure of Example 8 giving 1.2 g. of the title compound, m.p. about 114-°115° C.

Workup

  1. customThe title compound was prepared
  2. customThe reaction afforded 8.2 g
  3. customm.p. about 114-°115° C.

Sources & evidence

ORD record
ord-250cdea1cf9b402294ff7dc864f2df2c
Source dataset
uspto-grants-1988_09
Patent number
US04769482

Reaction notes

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