Sulfuric Acid → 2,3,4,5-Tetrafluorobenzoic acid

Participants

Reaction Steps

Decarboxylation of 3,4,5,6-tetrafluorophthalic acid was carried out by following the procedure of Example 1, except that 238 g (1.00 mole) of 3,4,5,6-tetrafluorophthalic acid, 13.8 g (0.140 mole) of sulfuric acid, 5.5 g (0.042 mole) of ammonium sulfate, 22.2 g (0.30 mole) of calcium hydroxide, and 480 g of water were used [pH 1.89 at 70° C. at the time of charging]. This example was found to have produced 2,3,4,5-tetrafluorobenzoic acid in a yield of 95.4 mole %.

Provenance & Evidence