Water → 3,4,5,6-Tetrafluorophthalic acid

HRID 622263Notes

Reaction equation

HRID 622263 reaction equation
[F:1][C:2]1[C:3]([F:15])=[C:4]([F:14])[C:5]([F:13])=[C:6]2[C:11](=[O:12])[O:10][C:8](=[O:9])[C:7]=12.[OH2:16]>>[F:1][C:2]1[C:3]([F:15])=[C:4]([F:14])[C:5]([F:13])=[C:6]([C:11]([OH:10])=[O:12])[C:7]=1[C:8]([OH:16])=[O:9]

Participants

3

Reactant 2

HCID 962WaterHCID 69545Tetrafluorophthalic anhydride

Product 1

HCID 695443,4,5,6-Tetrafluorophthalic acidYield 82%

Procedure

After mixing 110 g (0.5 mol) of tetrafluorophthalic anhydride and 150 ml of water, the mixture was refluxed for about one hour. After cooling the reaction mixture, crystals deposited were collected by filtration and dried to provide 97.6 g (yield 82%) of tetrafluorophthalic acid as white crystals. If necessary, the crystals could be further purified by recrystallization from an aqueous 6N hydrochloric acid solution.

Workup

  1. temperaturethe mixture was refluxed for about one hour
  2. temperatureAfter cooling the reaction mixture, crystals
  3. filtrationdeposited were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-8224410557cc44fa91bc7e07521ee82e
Source dataset
uspto-grants-1988_09
Patent number
US04769493

Reaction notes

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