1-Phenyl-2-(pyridin-2-yl)ethanamine → N-Methyl-1-(3-pyridinyl)-2-phenylethylamine

HRID 622271Notes

Reaction equation

HRID 622271 reaction equation
N1[CH:6]=[CH:5][C:4]([CH:7]([NH2:15])[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:3]C=1.C1(C(N)C[C:24]2C=CC=C[N:25]=2)C=CC=CC=1.[C:31]1(C(N)CC2C=NC=CC=2)C=CC=CC=1.C1(C(N)CC2C=CN=CC=2)C=CC=CC=1.N1C=CC=C(C(N)CC2C=CC=CC=2)C=1.CNC(C1C=CC=CN=1)CC1C=CC=CC=1.CNC(C1C=CN=CC=1)CC1C=CC=CC=1.CNC(C1C=CC=CC=1)CC1C=CC=CN=1.CNC(C1C=CC=CC=1)CC1C=NC=CC=1.CNC(C1C=CC=CC=1)CC1C=CN=CC=1>>[CH3:31][NH:15][CH:7]([C:4]1[CH:3]=[N:25][CH:24]=[CH:6][CH:5]=1)[CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

11

Reactant 10

HCID 30384851-Phenyl-2-(pyridin-2-yl)ethanamineHCID 99903262-Phenyl-1-(pyridin-4-yl)ethan-1-amine dihydrochlorideHCID 103527112-Phenyl-1-pyridin-3-YL-ethylamineHCID 104653421-Phenyl-2-(pyridin-4-yl)ethanamineHCID 160619321-Phenyl-2-(3-pyridinyl)ethylamineHCID 21293884N-methyl-1-(2-pyridinyl)-2-phenylethylamineHCID 21293894N-methyl-1-(4-pyridinyl)-2-phenylethylamineHCID 54097355N-methyl-1-phenyl-2-(4-pyridinyl)ethylamineHCID 54145007Methyl[1-phenyl-2-(pyridin-2-yl)ethyl]amineHCID 54288117HCID 54288117, compound

Product 1

HCID 21620713N-Methyl-1-(3-pyridinyl)-2-phenylethylamine

Procedure

By procedures essentially the same as those described above, and by substituting 1-(2-pyridinyl)-2-phenylethylamine, 1-(4-pyridinyl)-2-phenylethylamine, 1-phenyl-2-(2-pyridinyl)ethylamine, 1-phenyl-2-(3-pyridinyl)ethylamine, or 1-phenyl-2-(4-pyridinyl)ethylamine for 1-(3-pyridinyl)-2-phenylethylamine; the corresponding N-methyl-1-(2-pyridinyl)-2-phenylethylamine, N-methyl-1-(4-pyridinyl)-2-phenylethylamine, N-methyl-1-phenyl-2-(2-pyridinyl)ethylamine, N-methyl-1-phenyl-2-(3-pyridinyl)ethylamine, or N-methyl-1-phenyl-2-(4-pyridinyl)ethylamine may be respectively prepared.

Sources & evidence

ORD record
ord-baa1673506e84bfdab697d52fb1155ed
Source dataset
uspto-grants-1988_09
Patent number
US04769466

Reaction notes

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