1,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)- → HCID 21287694, compound

HRID 622362Notes

Reaction equation

HRID 622362 reaction equation
C1(C2ON=C([C:9]3[N:13]4[C:14]5[C:19]([C:20](=[O:25])[N:21]([CH:22]6[CH2:24]C6)[C:12]4=[CH:11][N:10]=3)=[C:18](Cl)[CH:17]=[CH:16][CH:15]=5)N=2)CC1.C1([N:30]2[C:39](=[O:40])[C:38]3[C:33](=[CH:34]C=CC=3Cl)[NH:32][C:31]2=O)CC1.C1(C2ON=C(C[N+]#[C-])N=2)CC1>>[CH:38]1([C:39]2[O:40][N:32]=[C:31]([C:11]3[N:10]=[CH:9][N:13]4[C:14]5[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=5)[C:20](=[O:25])[N:21]([CH2:22][CH3:24])[C:12]=34)[N:30]=2)[CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 107493421,2,4-Oxadiazole, 5-cyclopropyl-3-(isocyanomethyl)-HCID 21287678HCID 21287678, compoundHCID 86742425HCID 86742425, compound

Product 1

HCID 21287694HCID 21287694, compound

Procedure

3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl-4,5-dihydro-4-cyclopropyl-5-oxo-6-chloro-imidazo(1,5-a)quinazoline. M.p. 232°-235° C. by reaction between 3-cyclopropyl-5-chloro-1,2,3,4-tetrahydro-2,4-dioxo-quinazoline and 5-cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole.

Sources & evidence

ORD record
ord-04d999659ce54889a62d2c348f2ba747
Source dataset
uspto-grants-1988_09
Patent number
US04771051

Reaction notes

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