HCID 14234723, compound → HCID 14234705, compound

HRID 622369Notes

Reaction equation

HRID 622369 reaction equation
[CH:1]([C@H:4]1[C:9](=[S:10])[N:8]([CH2:11][C:12]([O:14][C@@H](C)C(OC)=O)=[O:13])[C:7]2[CH:21]=[CH:22][CH:23]=[C:24]([CH:25]([CH3:27])[CH3:26])[C:6]=2[O:5]1)([CH3:3])[CH3:2]>CO>[CH:1]([C@H:4]1[C:9](=[S:10])[N:8]([CH2:11][C:12]([OH:14])=[O:13])[C:7]2[CH:21]=[CH:22][CH:23]=[C:24]([CH:25]([CH3:27])[CH3:26])[C:6]=2[O:5]1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 14234723HCID 14234723, compound

Product 1

HCID 14234705HCID 14234705, compoundYield 61.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-Methyl 2-[(S)-3,4-dihydro-2,8-diisopropyl-3-thioxo-2H-1,4-benzoxazin-4-yl]acetoxypropionate (1.1 g) was hydrolyzed and worked up in the manner same as that used in Example 22 to yield (S)-(-)-3,4-dihydro-2,8-diisopropyl-3-thioxo-2H-1,4-benzoxazine-4-acetic acid (0.53 g), mp 109°-110° C. [α]D23 -105° MeOH).

Sources & evidence

ORD record
ord-d38618c3b2894228aaf9b67ebc3b37e7
Source dataset
uspto-grants-1988_09
Patent number
US04771050

Reaction notes

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