Dimethylformamide → 2-isopropyl-4H-benzo[1,4]oxazin-3-one

Participants

Reaction Steps

A mixture of 2-(2-bromo-3-methylbutyryl)aminophenol (58.0 g), powdered potassium carbonate (38.3 g) and N,N-dimethylformamide (200 ml) was stirred at room temperature for 2 hours. The mixture was diluted with water and the precipitate was collected to yield 2-isopropyl-2H-1,4-benzoxazin-3(4H)-one as crystals. Yield was 38.1 g (93.4%). Recrystallization from ethanol gave colorless plates, mp 118°-119° C. In the same manner as in Reference Example 1, the following compounds were obtained.

Provenance & Evidence