HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (S)-2,8-diisopropyl-2H-1,4-benzoxazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (R)-2-(2-bromo-3-methylbutyryl)amino-6-isopropylphenol | HCID 6932486 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-2,8-diisopropyl-2H-1,4-benzoxazin-3(4H)-one | HCID 7210282 | 80.3% |
Reaction Steps
A solution of (R)-2-(2-bromo-3-methylbutyryl)amino-6-isopropylphenol (18.5 g) in dimethylformamide (120 ml) was treated with powdered potassium carbonate (9.75 g) at room temperature for 3 hours. Dilution with water gave crystals, which were recrystallized from 2-propanol to yield (S)-2,8-diisopropyl-2H-1,4-benzoxazin-3(4H)-one as colorless prisms (11.0 g, 80.3%), mp 151°-152° C., [α]D23 -5.6° (c=1.0, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04771050 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-f6e5f76c6c214c99bd6bd590bbd78c10 |
| Source note | uspto-grants-1988_09 |