Ammonia → HCID 21293085, compound

Participants

Reaction Steps

3-(5-Bromo-3-methylpyrid-2-ylamino)propylamine (0.713 g) was added dropwise to a stirred solution of 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (0.639 g) in methanol (25 ml) at room temperature. After 4 hours at room temperature, methanolic ammonia (25 ml) was added at 0°-5° C. with stirring, the mixture allowed to stand overnight, then evaporated in vacuo. The residue was chromatographed on silica in 10% CH3OH/CHCl3. The product was crystallised from ethanol to give 4-amino-3-[3-(5-bromo-3-methylpyrid-2-ylamino)propylamino]-1,2,5-thiadiazole-1-oxide (0.322 g, 32%) m.p. 204°-205° C.

Provenance & Evidence