HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzylamine → HCID 21293092, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | 3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide | HCID 12913947 | — |
| Reactant | HCID 14397364 | HCID 14397364 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21293092 | HCID 21293092 | 41.1% |
Reaction Steps
3-(5-Bromo-3-methylpyrid-2-ylamino)propylamine (1.0 g) was reacted with 3,4-dimethoxy-1,2,5-thiadiazole-1-oxide (0.65 g) in methanol overnight. p-Fluorobenzylamine (0.51 g) was added and the reaction mixture was stirred for 2 hours. The product was filtered off and recrystallised from ethanol to yield 4-(p-fluorobenzylamino)-3-[3-(5-bromo-3-methylpyrid-2-ylamino)propylamino]-1,2,5-thiadiazole-1-oxide (0.77 g, 40%) m.p. 125°-126° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04771058 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-a6960ea2e67f460cac08a0daab32f27d |
| Source note | uspto-grants-1988_09 |