Acetamide, N-(1,4-dihydro-3-chloro-1,4-dioxo-2-naphthyl)- → HCID 2926585, compound

Participants

Reaction Steps

A mixture of 500 mg of 2-acetylamino-3-chloro1,4-naphthoquinone, 880 mg of N-benzylpiperazine and 40 ml of absolute ethanol was heated at reflux for 3 hours, then the solvent was removed. The remainder was passed through a small plug of silica gel and eluted with chloroform. The eluate was concentrated to a solid which was recrystallized from dichloromethane/hexane, giving 700 mg of the desired product, mp 153-155°C.

Provenance & Evidence