HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 622393Generated: October 26, 2026
1-Piperazinecarboxylic acid, ethyl ester → 4-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl ester
https://huagongshe.com/reaction/622393
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | 2,3-Epoxy-2-methyl-1,4-naphthoquinone | HCID 85845 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(1,4-Dihydro-3-methyl-1, 4-dioxo-2-naphthalenyl)-1-piperazinecarboxylic acid, ethyl ester | HCID 14278765 | 30.5% |
Reaction Steps
A mixture of 1.88 g of 2,3-epoxy-3-methyl-1,4-naphthoquinone, 3.16 g of piperazinecarboxylic acid, ethyl ester and 100 ml of absolute ethanol was stirred for 12 hours at 50°C. The solvent was then removed and the remainder filtered through a one inch plug of silica gel and eluted with chloroform. The eluate was evpaorated, giving 1 g of the desired product as a viscous red oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04771061 |
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| Source dataset | uspto-grants-1988_09 |
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| ORD ID | ord-46c1213e5f3d46c9a61253a3964493a3 |
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| Source note | uspto-grants-1988_09 |
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