1-Piperazinecarboxaldehyde → HCID 178521668, compound

HRID 622397Notes

Reaction equation

HRID 622397 reaction equation
[O:1]1[CH:11]2[CH:2]1[C:3](=[O:13])[C:4]1[C:9]([C:10]2=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:14]1([CH:20]=[O:21])[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(O)C>[OH:1][C:11]1[C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:13])[C:2]=1[N:17]1[CH2:18][CH2:19][N:14]([CH:20]=[O:21])[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 821911-PiperazinecarboxaldehydeHCID 858442,3-Epoxy-2,3-dihydro-1,4-naphthoquinone

Product 1

HCID 178521668HCID 178521668, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.48 g of 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone, 2.28 of 1-piperazinecarboxaldehyde and 200 ml of absolute ethanol was stirred for 20 hours, then concentrated to one-half its original volume and refrigerated, overnight. The solid was collected and recrystallized from dichloromethane/ethanol, giving 2.65 g of the desired product, mp 200-203°C.

Workup

  1. concentrationconcentrated to one-half its original volume
  2. customovernight
  3. customThe solid was collected
  4. customrecrystallized from dichloromethane/ethanol

Sources & evidence

ORD record
ord-30916243c1c24c59b7b07260cc6f64f7
Source dataset
uspto-grants-1988_09
Patent number
US04771061

Reaction notes

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