反应详情

53 ml of anhydrous pyridine were added to a mixture of 3.34 g of 4-piperidone hydrochloride monohydrate and 2.0 g of o-methylhydroxylamine hydrochloride, and the mixture was kept stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off, and the crystalline residue was washed with ethyl acetate and collected by filtration. The crystals were washed with saturated aqueous sodium bicarbonate solution until basic and then extracted with chloroform. The chloroform layer was dried over anhydrous magnesium sulfate and the solvent was stripped off, giving 2.5 g of the title compound.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. washthe crystalline residue was washed with ethyl acetate
4. filtrationcollected by filtration
5. washThe crystals were washed with saturated aqueous sodium bicarbonate solution until basic
6. extractionextracted with chloroform
7. dry with materialThe chloroform layer was dried over anhydrous magnesium sulfate