Hydrochloric Acid → (2S,4R)-4-Hydroxypyrrolidine-2-carboxamide Hydrochloride

Participants

Reaction Steps

4.50 g of the product obtained in step (1) above were suspended in 45 ml of ethyl acetate and then 14.9 ml of 4.84M hydrogen chloride in ethyl acetate were added under ice-cooling. The mixture was stirred at 25°-30° C. for 30 minutes, after which the reaction mixture was worked up in the same manner as in Preparation 4(2) to give 3.21 g of the title compound.

Provenance & Evidence