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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 622465Generated: October 31, 2026

Dimethyl acetylenedicarboxylate → 1-(3-Ethoxy-4-methoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene

https://huagongshe.com/reaction/622465

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl acetylenedicarboxylateHCID 12980—
Reactant3-Ethoxy-4-methoxybenzaldehydeHCID 244728—
Reactant2-Bromo-3,4,5-trimethoxybenzaldehyde dimethylacetalHCID 15914458—
Product1-(3-Ethoxy-4-methoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthaleneHCID 1391082665%

Reaction Steps

2-Bromo-3,4,5-trimethoxybenzaldehyde dimethylacetal, 3-ethoxy-4-methoxybenzaldehyde and dimethyl acetylenedicarboxylate are treated in the same manner as described in Example 1, whereby 1-(3-ethoxy-4-methoxyphenyl)-2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxynaphthalene is obtained as colorless needles. Yield: 65%

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04771072
Source datasetuspto-grants-1988_09
ORD IDord-42bd526bda2d42a2a43a915cae4228a3
Source noteuspto-grants-1988_09