反应详情

To 0.80 g (2.8 mmol) of the 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid in 10 ml of acetonitrile and 0 43 g (2.8 mmol) of 1,8-diazobicyclo[5.4.0]undec-7-ene was added 0.35 g (3.1 mmol) of the N-ethyl-3-aminopyrrolidine. The mixture was refluxed for one hour and stirred overnight. The solids were filtered and washed with ether:acetonitrile (6:1), to give 0.81 g of the title compound, mp 236°-238° C.

1. temperatureThe mixture was refluxed for one hour
2. filtrationThe solids were filtered
3. washwashed with ether:acetonitrile (6:1)