HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 622515Generated: November 1, 2026
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → HCID 13772747, compound
https://huagongshe.com/reaction/622515
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 11055142 | — |
| Reactant | Ethyl-pyrrolidin-3-ylmethyl-amine | HCID 13491786 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 13772747 | HCID 13772747 | 80% |
Reaction Steps
A suspension of 5.7 g (20 mmole) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, 10.3 (80 mmole) of 3-ethylaminomethylpyrrolidine and 125 ml of acetonitrile was stirred at room temperature for 0.5 hours after an initial exotherm (60° C). The solid was removed by filtration, washed with acetonitrile, and dried in vacuo to give 6.0 g (80%) of the title compound, mp 268°-270° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04771054 |
|---|
| Source dataset | uspto-grants-1988_09 |
|---|
| ORD ID | ord-f1c9a9ba68c64266a77b6dcde5b527f8 |
|---|
| Source note | uspto-grants-1988_09 |
|---|
