Methyl propionate → HCID 14356366, compound

Participants

Reaction Steps

To a solution of 2.0 g of (3S,4R)-4-azido-3-tritylamino-2-azetidinone in 35 ml of toluene is added 1.14 g of methyl propionate and the mixture is refluxed for 2 hours. The solvent is then distilled off under reduced pressure and the residue is purified by silica gel column chromatography using n-hexane-ethyl acetate (2:1). The earlier eluate fractions are combined and concentrated under reduced pressure to give 0.818 g of (3S,4R)-[5-methoxycarbonyl)-1,2,3-triazol-1-yl]-3-tritylamino-2-azetidinone (compound A).

Provenance & Evidence