Ammonia → HCID 14257302, compound

Participants

Reaction Steps

To a solution of 4.35 g of (3R,4R)-4-[[(methoxycarbonyl)methyl]thio]-3-tritylamino-2-azetidinone in 45 ml of ethanol is added 11 ml of 25 to 28% aqueous ammonia and the reaction mixture is allowed to stand at room temperature for 2 days. The mixture is further treated in the same manner as described in Reference Example 8 to give 1.804 g of (3R,4R)-4-[[(aminocarbonyl)methyl]thio]-3-tritylamino-2-azetidinone.

Provenance & Evidence