反应详情

To 20 parts by volume of chloroform was added 0.96 part by weight of N-acetylphenylglycine. With ice cooling, 1.03 parts by weight of dicyclohexylcarbodiimide was added, and the mixture was stirred. Furthermore, 0.83 part by weight of phenylglycine methyl ester was added, and about 3 hours later, the temperature was returned to room temperature. The mixture was then stirred overnight. After the reaction, the precipitate was collected by filtration, and washed with chloroform. The filtrate was concentrated to dryness. The resulting solid was washed with ethyl acetate, and extracted with a mixture of chloroform and petroleum ether to give 1.2 parts by weight of the captioned compound having a melting point of 198° to 200° C.

1. customabout 3 hours
2. customwas returned to room temperature
3. stirringThe mixture was then stirred overnight
4. customAfter the reaction
5. filtrationthe precipitate was collected by filtration
6. washwashed with chloroform
7. concentrationThe filtrate was concentrated to dryness
8. washThe resulting solid was washed with ethyl acetate
9. extractionextracted with a mixture of chloroform and petroleum ether
10. customto give 1.2 parts by weight of the captioned compound