2,3-Dihydro-1H-indole-7-sulfonamide → 1H-Indole-7-sulfonamide

Participants

Reaction Conditions

Reaction Steps

To a slurry of activated manganese dioxide (20 g) in methylene chloride (200 ml) was added indoline-7-sulfonamide (4.3 g). The mixture was stirred at 25° C. for 24 hours. The solid was removed by filtration and the filtrate concentrated and hexane added until crystallization occurred. The pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.).

Provenance & Evidence