反应详情

A mixture of 3 g 5-trifluoromethoxy-2-pyridinemethanol is vigorously stirred in 120 mL water at 5° C. To this mixture is added in several portions 3.0 g potassium permanganate during which time the temperature rises to 25° C. After a further 30 minutes at 25° C., the mixture is filtered, the solid washed several times with water, the filtrate and washings combined and the pH adjusted to 5. The solution is concentrated to a small volume and extracted with ethyl acetate several times. The extract is washed, dried and concentrated to give 5-trifluoromethoxy-2-pyridinecarboxylic acid.

1. customrises to 25° C
2. filtrationthe mixture is filtered
3. washthe solid washed several times with water
4. concentrationThe solution is concentrated to a small volume
5. extractionextracted with ethyl acetate several times
6. washThe extract is washed
7. customdried
8. concentrationconcentrated