Pyridine → HCID 13755214, compound

Participants

Reaction Steps

4.3 ml (0.053 mole) of pyridine and 3.6 ml (0.051 mole) of propionyl chloride are successively added dropwise to 11 g (0.048 mole) of 5-amino-1-(3,5-dichloropyrid-2-yl)-pyrazole in 80 ml of methylene chloride at room temperature, with stirring. When the addition has ended, stirring is continued for a further 5 hours, the mixture is diluted with 70 ml of methylene chloride, washed successively with dilute hydrochloric acid, saturated sodium bicarbonate solution and sodium chloride solution and dried over magnesium sulphate and the solvent is removed in vacuo. 12.5 g (91.4% of theory) of 5-propionamido-1-(3,5-dichloropyrid-2-yl)-pyrazole of melting point 116°-124° C. are obtained.

Provenance & Evidence