Nitric Acid → HCID 13755215, compound

Participants

Reaction Steps

1.5 ml (0.033 mole) of 98% strength nitric acid are added to 9.0 g (0.032 mole) of 5-propionamido-1-(3,5-dichloro-pyrid-2-yl)-pyrazole and 3.2 ml (0.035 mole) of acetic anhydride in 35 ml of glacial acetic acid at 10° C. and the mixture is stirred at room temperature for 6 hours. For working up, the mixture is concentrated in vacuo, the residue is taken up in 100 ml of methylene chloride and the mixture is neutralized with sodium bicarbonate solution, washed with sodium chloride solution, dried over magnesium sulphate and freed from the solvent in vacuo. 9.3 g (89% of theory) of 5-propionamido-1-(3,5-dichloropyrid-2-yl)-4-nitro-pyrazole of melting point 53° C.-56° C. are obtained.

Provenance & Evidence