HRID622637

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)O

HCID2724765

L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-

C19H28N2O6

结构：COC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCNC(=O)OCc1ccccc1.O=C(O)C(F)(F)F

HCID131667640

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC(=O)OCc1ccccc1.O=C(O)C(F)(F)F

HCID131715717

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)O

溶剂HCID83589

L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester

C17H23NO6

PROCEDURE

实验过程

Instead of Boc-Lys(Z)-OH in (b), Boc-Glu(Bzl)-OH was used as a starting compound to obtain H-Glu(Bzl)-Pro-OMe trifluoroacetate (oil).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b912040337c4ad59022cff53b29b689
来源数据集: uspto-grants-1988_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04772587
来源说明: uspto-grants-1988_09

反应 SMILES

N(C(OC(C)(C)C)=O)[C@H](C(O)=O)CCCCN[C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9].[NH2:28][C@H:29]([C:45]([N:47]1[CH2:55][CH2:54][CH2:53][C@H:48]1[C:49]([O:51][CH3:52])=[O:50])=[O:46])[CH2:30][CH2:31]CCNC(OCC1C=CC=CC=1)=O.[F:56][C:57]([C:60]([OH:62])=[O:61])([F:59])[F:58]>N(C(OC(C)(C)C)=O)[C@H](C(O)=O)CCC(=O)OCC1C=CC=CC=1>[NH2:28][C@H:29]([C:45]([N:47]1[CH2:55][CH2:54][CH2:53][C@H:48]1[C:49]([O:51][CH3:52])=[O:50])=[O:46])[CH2:30][CH2:31][C:8](=[O:9])[O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1.[F:56][C:57]([C:60]([OH:62])=[O:61])([F:59])[F:58]