Ammonia → HCID 14254895, compound

HRID 622644Notes

Reaction equation

HRID 622644 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[CH:12])[C:8](=[O:13])[CH2:7][CH2:6]1)=O.[NH3:14]>CO>[O:13]=[C:8]1[N:9]([CH2:10][C:11]#[CH:12])[CH:5]([C:3]([NH2:14])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254893HCID 14254893, compound

Product 1

HCID 14254895HCID 14254895, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-(2-propynyl)-2-pyrrolidinone (5.1 g) and sieve dried methanol (250 ml) was treated with anhydrous ammonia for ten minutes and was then allowed to stand overnight at ambient temperature. The solution was concentrated to afford an oil which crystallized (4.81 g). Recrystallization from 95% ethanol (20 ml) gave 3.07 g of almost colorless crystals, mp 145°-147° C.

Workup

  1. concentrationThe solution was concentrated
  2. customto afford an oil which
  3. customcrystallized (4.81 g)
  4. customRecrystallization from 95% ethanol (20 ml)
  5. customgave 3.07 g of almost colorless crystals, mp 145°-147° C.

Sources & evidence

ORD record
ord-551566aee250453cbf193c095e594171
Source dataset
uspto-grants-1988_09
Patent number
US04772601

Reaction notes

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