Ammonia → HCID 14254897, compound

HRID 622645Notes

Reaction equation

HRID 622645 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:8](=[O:19])[CH2:7][CH2:6]1)=O.[NH3:20]>CO>[O:19]=[C:8]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:5]([C:3]([NH2:20])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254896HCID 14254896, compound

Product 1

HCID 14254897HCID 14254897, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinone (5.52 g) in sieve dried methanol (175 ml) was treated with anhydrous ammonia for fifteen minutes and was allowed to stand at ambient temperature overnight. The solution was concentrated to a brown solid (3.33 g). The solid was recrystallized from toluene (100 ml) to give 2.03 g of slightly brown crystals, mp 146°-147.5° C.

Workup

  1. concentrationThe solution was concentrated to a brown solid (3.33 g)
  2. customThe solid was recrystallized from toluene (100 ml)
  3. customto give 2.03 g of slightly brown crystals, mp 146°-147.5° C.

Sources & evidence

ORD record
ord-3906cec052904402a89661d70844447c
Source dataset
uspto-grants-1988_09
Patent number
US04772601

Reaction notes

Loading…