Ammonia → HCID 14254899, compound

HRID 622646Notes

Reaction equation

HRID 622646 reaction equation
C[O:2][C:3]([CH:5]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:8](=[O:20])[CH2:7][CH2:6]1)=O.[NH3:21]>CO>[O:20]=[C:8]1[N:9]([CH2:10][C:11]#[C:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:5]([C:3]([NH2:21])=[O:2])[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14254898HCID 14254898, compound

Product 1

HCID 14254899HCID 14254899, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

An ice water chilled solution of 5-methoxycarbonyl-1-[4-(1-piperidinyl)-2-butynyl]-2-pyrrolidinone (5.44 g) in sieve dried methanol (175 ml) was treaed with anhydrous ammonia for fifteen minutes and was allowed to stand at ambient temperature overnight. The solution was concentrated to a brown solid (5.00 g). The solid was recrystallized from toluene (125 mL) to give 3.85 g of slightly brown crystals, mp 143°-145° C.

Workup

  1. concentrationThe solution was concentrated to a brown solid (5.00 g)
  2. customThe solid was recrystallized from toluene (125 mL)
  3. customto give 3.85 g of slightly brown crystals, mp 143°-145° C.

Sources & evidence

ORD record
ord-7abc506f807c4d8c91044a94eae8d5af
Source dataset
uspto-grants-1988_09
Patent number
US04772601

Reaction notes

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