HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 622659Generated: October 31, 2026
Water → 1-Pyrid-2-yl-2-methylsulphonyl-4-phenyl-pyrazolin-5-one
https://huagongshe.com/reaction/622659
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 4-Phenyl-2-(pyridin-2-yl)-1,2-dihydro-3H-pyrazol-3-one | HCID 13590473 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Pyrid-2-yl-2-methylsulphonyl-4-phenyl-pyrazolin-5-one | HCID 13786779 | 71.3% |
Reaction Steps
23.7 g (0.1 mole) of 1-pyrid-2-yl-4-phenyl-pyrazolin-5-one are dissolved in 200 ml of dioxane. After addition of 10.1 g (0.1 mole) of triethylamine, 11.5 g (0.1 mole) of methanesulphonyl chloride are added dropwise at room temperature, while cooling gently. The mixture is subsequently stirred at room temperature for a further 2 hours and at 70° C. for 5 hours, cooled and stirred into 1 l of water. The crystals are filtered off with suction, dried in air and recrystallized from ethanol. 22.5 g (71% of theory) of 1-pyrid-2-yl-2-methylsulphonyl-4-phenyl-pyrazolin-5-one of melting point 112°-114° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04772608 |
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| Source dataset | uspto-grants-1988_09 |
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| ORD ID | ord-626bc5a71f4b4fdca6f17111997af335 |
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| Source note | uspto-grants-1988_09 |
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