N-bromobutanimide → HCID 136047415, compound

HRID 622668Notes

Reaction equation

HRID 622668 reaction equation
[Br:1]N1C(=O)CCC1=O.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][N:16]2[CH:24]=[N:23][C:22]3[C:21](=[O:25])[NH:20][C:19]([NH2:26])=[N:18][C:17]2=3)[CH:10]=1>C(O)(=O)C>[Br:1][C:24]1[N:16]([CH2:15][C:11]2[CH:10]=[N:9][CH:14]=[CH:13][CH:12]=2)[C:17]2[N:18]=[C:19]([NH2:26])[NH:20][C:21](=[O:25])[C:22]=2[N:23]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 1360655552-Amino-9-[(pyridin-3-yl)methyl]-3,9-dihydro-6H-purin-6-one

Product 1

HCID 136047415HCID 136047415, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

N-Bromosuccinimide (1.59 g; 8.95 mmol) was added to a suspension of 9-[(3-pyridyl)methyl]guanine (2.0 g; 8.14 mmol) in glacial acetic acid (20 ml) and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was concentrated under reduced pressure and then diluted with water and filtered. The crude product was triturated with water, filtered, and washed with water and dried. Yield 1.91 g; mp >300° C.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additiondiluted with water
  3. filtrationfiltered
  4. customThe crude product was triturated with water
  5. filtrationfiltered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-58abcdac4fe541108a739591e3661f26
Source dataset
uspto-grants-1988_09
Patent number
US04772606

Reaction notes

Loading…