4-Piperidinamine, 1-(2-(1H-indol-3-yl)ethyl)-, hydrate → HCID 13883142, compound

Participants

Reaction Steps

A melt of 3-[2-(4-amino-1-piperidyl)ethyl]indole (1.0 g, 4.11 mmol), 2-hydroxypyridine (0.3 g, 3.16 mmol) and 2-methoxycarbonyl-1-methyl-1H-imidazole (0.57 g, 4.07 mmol) was heated at 160° C. for 3 hours under N2. More 2-methoxycarbonyl-1-methyl-1H-imidazole (5 drops) was added and heating continued for a further 11/2 hours. The mixture was cooled and chromatographed on silica (100-200 aktiv) eluting with absolute ethanol. The title compound was isolated as a brown glass (0.97 g,).

Provenance & Evidence