HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(2-Tetrahydrofurylmethyl)piperid-4-one oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (Tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 266119 | — |
| Reactant | N-Piperidin-4-ylidenehydroxylamine | HCID 12849639 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | 1-(2-Tetrahydrofurylmethyl)piperid-4-one oxime | HCID 21291512 | 535.9% |
Reaction Steps
A mixture of piperid-4-one oxime (46 g; 0.04 moles), 2-tetrahydrofurylmethyl methanesulphonate (79.3 g; 0.44 moles) and anhydrous potassium carbonate (56.5 g; 0.40 moles) in methyl isobutyl ketone (625 ml), was boiled under reflux with stirring for 48 hours. After cooling, the reaction mixture was washed with brine, dried (Na2SO4), and the solvent removed in vacuo. The residue was crystallised from diisopropyl ether to give 1-(2-tetrahydrofurylmethyl)-piperid-4-one oxime (42.5 g), m.p. 104°-106°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04772618 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-de99814f1c6945d2932bb6a066032068 |
| Source note | uspto-grants-1988_09 |