Dimethylamine → HCID 15474173, compound

HRID 622683Notes

Reaction equation

HRID 622683 reaction equation
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[C:4]([S:13](Cl)(=[O:15])=[O:14])=[CH:3]1.[CH3:17][NH:18][CH3:19]>C(O)C>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[C:4]([S:13]([N:18]([CH3:19])[CH3:17])(=[O:15])=[O:14])=[CH:3]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 21291473HCID 21291473, compound

Product 1

HCID 15474173HCID 15474173, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-methyl-4-oxo-1,4-dihydroquinoline-3-sulphonyl chloride (2.4 g) and a solution of dimethylamine in ethanol (33% w/w; 50 ml) was stirred at room temperature for 30 minutes. The precipitated solid was filtered off and then boiled with dichloromethane (100 ml). The mixture was filtered and the filtrate evaporated to dryness to provide a white solid which was crystallised from methanol to give the novel compound 1,N,N-trimethyl-4-oxo-1,4-dihydroquinoline-3-sulphonamide, m.p. 225°-226°.

Workup

  1. filtrationThe precipitated solid was filtered off
  2. filtrationThe mixture was filtered
  3. customthe filtrate evaporated to dryness
  4. customto provide a white solid which
  5. customwas crystallised from methanol

Sources & evidence

ORD record
ord-541657d2793c48feb3a1cbf78dabb337
Source dataset
uspto-grants-1988_09
Patent number
US04772614

Reaction notes

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