HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 14302387, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Nitrophenol | HCID 11137 | — |
| Reactant | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 14302387 | HCID 14302387 | 70.7% |
Reaction Steps
A mixture of 1-methyl-2-(chloromethyl)benzimidazole (9.8 g), 3-nitrophenol (7.5 g), cesium carbonate (17.6 g), sodium carbonate (5.7 g), potassium iodide (0.5 g) and acetone (250 ml) is heated at reflux overnight. The mixture is filtered and the resulting solution is partially concentrated. A crystalline solid forms which is filtered and dried, giving 10.8 g (70% yield) of title compound, m.p. 183°-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04772703 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-3fd11127bb0e4f99820fc22c2bdcc9cc |
| Source note | uspto-grants-1988_09 |