3-Phenylpiperazin-2-one → 2-Phenylpiperazine

HRID 622777Notes

Reaction equation

HRID 622777 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1([CH:13]2[NH:18][CH2:17][CH2:16][NH:15][C:14]2=O)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CCOCC>[C:7]1([CH:13]2[CH2:14][NH:15][CH2:16][CH2:17][NH:18]2)[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 2506813-Phenylpiperazin-2-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 2506732-PhenylpiperazineYield 83.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

To an ice-cooled stirred suspension of 25. g (0.66 mol) of lithium aluminum hydride in 2.6 liters of anhydrous ether was added in portions over 0.5 hour 30 g (0.17 mol) of 3-phenyl-2-piperazinone. The resulting mixture was heated at reflux for 20 hours and then cooled to 0° C. Isolation of the product by standard methods gave 23 g (83%) of 2-phenylpiperazine as an off-white solid (mp. 83°-85° C.).

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 20 hours

Sources & evidence

ORD record
ord-85cf50672a8d4374912fbcfa39ac8f63
Source dataset
uspto-grants-1988_09
Patent number
US04772705

Reaction notes

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