5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → 2-{2-[(5-Dimethylaminomethyl-2-furyl)methylthio]ethylamino}-5-nitro-4(3H)-pyrimidone

Participants

Reaction Steps

A mixture containing 2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamine (4.72 g; 22.0 mmoles) and 2-methylthio-5-nitro-4-hydroxypyrimidine (4.0 g; 21.37 mmoles) in 20 ml of ethanol was heated at reflux temperature for 18 hours. The reaction mixture was evaporated under reduced pressure, and the residue was recrystallized from 2-methoxyethanol to give 5.96 g of the title compound, mp 201°-204° C.

Provenance & Evidence