HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Pyridine, 4-(4-methyl-1-piperidinyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 4-Methylpyridine | HCID 7963 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-Pyrrolidinopyridine | HCID 75567 | — |
| Solvent | Water | HCID 962 | — |
| Product | Pyridine, 4-(4-methyl-1-piperidinyl)- | HCID 157352 | — |
Reaction Steps
The exact procedure of Example 5 for the preparation of 4-pyrrolidinopyridine was followed substituting 12.4 g (0.125 mole) of 4-methylpyridine in 18.6 ml of water for the aqueous pyrrolidine solution. After concentration of the toluene extracts, a quantitative yield of the title compound product was obtained as a reasonably pure oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04772713 |
| Source dataset | uspto-grants-1988_09 |
| ORD ID | ord-4d89b39baac641229be0725373966bcd |
| Source note | uspto-grants-1988_09 |